The hetergeneity of the brain makes designing a desired end drug distribution through pressurized catheters difficult. We present a method to utilize real-time MR monitoring of a co-infused Gd tracer during initial stages of the infusion to derive a real-time 3D estimate of the velocity front. We also describe a new algorithm that uses the velocity front to provide surgical feedback on the likely final infusion distribution.
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Brady M, Raghavan R, Alexander AL, Block WF. Controlling brain infusion distributions: Moving from surgical planning to real-time MR Guidance, p. 5539, Proc. of ISMRM 25th Annual Meeting 2017, Honolulu, Hawaii, April 2017