We present an intraoperative MRI protocol for stereotaxic surgery to precisely deliver induced pluripotent stem cells to targeted locations within the brain of a non-human primate model.
Previously, these surgeries were performed in stereotaxic operating rooms with no intraoperative imaging, or in a conventional MRI system without real-time guidance. Those environments complicate the goals of ensuring precise cannula tip placement before injection, and being able to perform the desired number of injections during the anesthesia window. Our platform enables surgeons to quickly achieve precise tip placement, and confirm via imaging that cells were deposited at the intended target.
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Olsen M, Vemilyea S, Lu J Brodsky EK, Guthrie S, Tao Y, Fekete F, Riedel M, Brunner K, Boettcher C, Bondarenko V, Alexander AL, Zhang S, Emborg M, Block WF. Targeted delivery of stem cells to the brain using real-time interventional MRI, p. 738, Proc. of ISMRM 25th Annual Meeting 2017, Honolulu, Hawaii, April 2017.